Mae Tho National Park is situated between the northern latitudes of 18 o 07' - 18 o 29' and the eastern longitudes of 98 o 8.5' - 98 o 24' . The National Park's headquarters is located at the Water Source Development Unit 6 (Doi Mae Tho), Ban Lao-li, Mu 9 (separated from Ban Maetho Mu 10), Tambon Bosali, Hot District, Chiang Mai Province.

The geographical features of the National Park consist of steep mountains (400-1,699 meters above the medium sea level), extending northwards in the same mountain range of Doi Inthanon. Mountains in the northern part of the area are about 20%-40% steeper than those in the southern part. The average altitude of the area is 1,000 meters above the medium sea level. Doi Kio Rai-mong is the highest mountaintop (1,699 meters above the medium sea level), located at Ban Pang Hin-fon, Mae-Chaem District. Meanwhile, the National Park's office is located at the approximate altitude of 1,200 meters above the medium sea level.

Wild animals found in the National Park include gaur, deer, goral, Muliacus Muntjak, bears, gibbons, monkeys, langur, masked palm civets, rabbits, wild boars, and elephants, inhabiting in Om-koi Sanctuary, Dong Sam-muen and Mae-pai Forests, peacocks, pheasants, red jungle fowls, parrots, Gracula Religiosa, Trogon, hawks, woodpeckers, constrictors, pythons, cobras, monitor lizards, ground lizards, turtles, soft-shelled turtles, frogs, small green frogs, bull frogs, and fish in gullies and rivers, particularly Mae-jam River.